Is pregabalin safe in liver disease?

Adjuvant analgesics such as tricyclic antidepressants and anti-convulsants may be used cautiously for cirrhotic patients with neuropathic pain. Gabapentin or pregabalin may be better tolerated in cirrhosis because of non-hepatic metabolism and a lack of anti-cholinergic side effects.

Does gabapentin destroy your liver?

No cases of acute liver failure or chronic liver injury due to gabapentin have been described. There is no information about cross reactivity with other compounds having similar structure (pregabalin). In general, gabapentin is well tolerated in patients with hypersensitivity reactions to other anticonvulsants.

Which painkiller is easiest on the liver?

Acetaminophen is broken down by the liver and can form byproducts that are toxic to the liver, so this warning is not completely without merit. But take it from a hepatologist, acetaminophen is the best option for pain relief for people with liver disease.

Can pregabalin cause liver damage?

Since its approval and more wide scale use, however, pregabalin has been linked to rare instances of clinically apparent liver injury. Most cases were mild and frequently without jaundice. The latency to onset of injury was short, symptoms of liver injury arising within 3 to 14 days.

What are the dangers of Lyrica?

Increased risk of sleepiness or dizziness

Decreased ability to participate in normal activities

Increased risk of injury

Depression

Risk of suicidal thoughts or actions

How dangerous is Lyrica?

While most serious side effects with Lyrica (pregabalin) occur in only a very small number of people, it is important you are aware of them. Serious, possibly life-threatening allergic reactions like angioedema or allergic reactions can occur with Lyrica or Lyrica CR.

Does Lyrica affect your kidneys?

Higher doses may result in more side effects. Lyrica is mainly excreted through the kidneys, and your dose for any use may need to be decreased if you have kidney disease. Your doctor will know how to adjust your doses based on a calculation of your kidney function.

Can Lyrica cause liver or kidney damage?

Lyrica (pregabalin) does not appear to have any negative effects of the liver. Pregabalin does not undergo any metabolism via the liver and does not induce or inhibit any liver enzymes.