Why treatment of cancer stem cells is more important than treatment of cancer cells?

Drug resistance in cancer stem cells It must be borne in mind that cancer stem cells are more resistant to chemotherapeutics than normal tumor cells. One particularly intriguing property of stem cells is that they express high levels of specific drug transporters.

What are the similarities between stem cells and cancer cells?

The functional capabilities of normal stem cells and tumorigenic cancer cells are conceptually similar in that both cell types are able to proliferate extensively. Indeed, mechanisms that regulate the defining property of normal stem cells – self-renewal – also frequently mediate oncogenesis.

Can stem cells help suppress the growth of a tumor?

Since CSCs can attract normal stem cells, normal stem cells can be potentially used to target CSCs in cancer therapy. Interactions between normal stem cells and CSCs suppress tumor proliferation, angiogenesis, and metastasis, and reduce inflammation and apoptosis.

Does chemotherapy affect stem cells?

Conventional chemotherapy initially kills most cancer cells and shrinks tumor size immediately, but the spared cancer stem cells eventually result in relapse and metastasis.

Does a bone marrow transplant cure cancer?

The goal of a bone marrow transplant is to cure many diseases and types of cancer. When the doses of chemotherapy or radiation needed to cure a cancer are so high that a person’s bone marrow stem cells will be permanently damaged or destroyed by the treatment, a bone marrow transplant may be needed.

How can stem cells help in the treatment of cancer?

The stem cell treatment will try to get the best out of the immune system for addressing the tumors. The antigens specific to cancer helped the development of antigen-specific immunotherapy. With dendritic cell vaccination, the body receives antigen and adjuvant to therapeutic T-cells.

How effective is stem cell treatment for cancer?

Stem cell transplants do not usually work against cancer directly. Instead, they help you recover your ability to produce stem cells after treatment with very high doses of radiation therapy, chemotherapy, or both.

How successful is stem cell treatment for cancer?

Another treatment to help kill cancer cells that might be in the returned stem cells involves giving anti-cancer drugs after transplant. The stem cells are not treated. After transplant, the patient gets anti-cancer drugs to get rid of any cancer cells that may be in the body. This is called in vivo purging.

How can stem cells be used to treat diseases and cancer?

Doctors have performed stem cell transplants, also known as bone marrow transplants. In stem cell transplants, stem cells replace cells damaged by chemotherapy or disease or serve as a way for the donor’s immune system to fight some types of cancer and blood-related diseases, such as leukemia, lymphoma, neuroblastoma and multiple myeloma.

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