Why is platinum used in cancer treatment?
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Why is platinum used in cancer treatment?
Platinum therapy is currently used in the treatment of various different cancer types. Platinum compounds cause apoptosis of cancer cells through changes in DNA structure, which inhibits DNA replication, transcription and cell division (the cell cycle).
Which chemotherapy drugs are carcinogenic?
Alkylating agents are classic carcinogens (methylnitrosourea, 7,12-dimethylbenzanthracene, diethylnitrosoamine) and also they are classic anticancer drugs (melphalan, chlorambucil, busulfan, cyclophosphamide, the nitrosoureas, cisplatinum and carboplatin).
How does platinum chemotherapy work?
Platinum-Based Drugs (Cisplatin, Carboplatin) These drugs form highly reactive platinum complexes that bind and crosslink DNA, a double-stranded molecule inside the nucleus of the cell that controls cellular activity. The chemical crosslinking within the DNA prevents cancer cells from growing and causes them to die.
Why Cisplatin is used as an anticancer drug?
Cisplatin binds to the N7 reactive center on purine residues and as such can cause deoxyribonucleic acid (DNA) damage in cancer cells, blocking cell division and resulting in apoptotic cell death. The 1,2-intrastrand cross-links of purine bases with cisplatin are the most notable among the changes in DNA.
Is platinum used in cancer treatment?
Platinum-based agents are important drugs or drug candidates for cancer chemotherapy. Traditional platinum drugs including the globally approved cisplatin, carboplatin and oxaliplatin are neutral platinum (II) complexes with two amine ligands and two additional ligands that can be aquated for further binding with DNA.
How are carcinogens treated?
Six Ways to Detox Your Life from Carcinogens
- Stay Active. Exercising for as little as 30 minutes will reduce the risk of cancer for a multitude of reasons.
- Choose a Cancer-Fighting Diet.
- One Drink a Day.
- Be Aware of Indoor Toxins.
- Live Tobacco-Free.
- Avoid Sun Damage.
Why is platinum effective?
Platinum-based drugs are effective against cancer because at their centre is a platinum atom joined to two ammonion molecules and two chloride ions. The compound is negatively charged, but when it enters the cancer cell it becomes positively charged because the chloride ions are replaced by water molecules.
Is there platinum in cisplatin?
Cisplatin, a platinum-based drug, is used in combination chemotherapy for a wide range of solid tumors.
Is cisplatin a carcinogen?
Traditionally, cisplatin has not been regarded among chemotherapeutic drugs as a carcinogenic risk to humans because it is not a classical alkylating agent.