Why does streptomycin kill bacterial cells but not human cells?
Table of Contents
- 1 Why does streptomycin kill bacterial cells but not human cells?
- 2 How does streptomycin prevent bacterial growth?
- 3 Why is streptomycin so important?
- 4 What bacteria is resistant to streptomycin?
- 5 Does streptomycin kill E coli?
- 6 What bacteria does streptomycin target?
- 7 How does fluoroquinolones affect and destroy bacteria?
- 8 How is streptomycin effective against E coli?
Why does streptomycin kill bacterial cells but not human cells?
Streptomycin is another broad spectrum antibiotic, but it only affects gram-negative bacteria. Unlike penicillin, it doesn’t target the cell membrane. Instead, it inhibits protein synthesis by the types of ribosomes specific to gram-negative bacteria.
How does streptomycin prevent bacterial growth?
Streptomycin irreversibly binds to the 16S rRNA and S12 protein within the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby inhibiting the initiation of protein synthesis.
How do penicillin and streptomycin kill bacteria?
Penicillin kills bacteria by inhibiting the proteins which cross-link peptidoglycans in the cell wall (Figure 8). When a bacterium divides in the presence of penicillin, it cannot fill in the “holes” left in its cell wall.
Why is streptomycin so important?
Because it was effective against a wide variety of diseases, streptomycin was used often, with the result that many initially sensitive microorganisms, including the bacterium that causes tuberculosis, became resistant to the antibiotic.
What bacteria is resistant to streptomycin?
Streptomycin inhibits protein synthesis by binding to the 30S subunit of the prokaryotic ribosome and was found to be effective not only against Gram-negative bacteria but also against the tubercle bacillus (Hopwood, 2007).
How does streptomycin work on E coli?
Streptomycin treatment enhances the growth of E. coli by nitrate respiration. To test the hypothesis that a streptomycin-induced increase in Nos2 mRNA levels fuels the growth of E.
Does streptomycin kill E coli?
Streptomycin treatment enhances the growth of E. coli by nitrate respiration.
What bacteria does streptomycin target?
Streptomycin is a strong base antibiotic produced by S. griseus. Waksman discovered this antibiotic in 1944. Streptomycin belongs to the glucosides (aminoglycosides) and is effective against a large number of both gram-positive and gram-negative bacteria, spirochaetes, that cause animal and plant diseases.
How does sulfonamides affect and destroy bacteria?
Sulfa drugs are bacteriostatic; i.e., they inhibit the growth and multiplication of bacteria but do not kill them. They act by interfering with the synthesis of folic acid (folate), a member of the vitamin B complex present in all living cells.
How does fluoroquinolones affect and destroy bacteria?
A fluoroquinolone is an antibiotic that destroys bacteria by interfering with its DNA replication. Early generation fluoroquinolones hamper bacterial DNA synthesis during replication primarily by inhibiting DNA gyrase, one enzyme required for bacterial (but not human) DNA replication.