Which of the following would result in a frameshift mutation?

A frameshift mutation is produced either by insertion or deletion of one or more new bases. Because the reading frame begins at the start site, any mRNA produced from a mutated DNA sequence will be read out of frame after the point of the insertion or deletion, yielding a nonsense protein.

What happens when a frameshift mutation occurs?

​Frameshift Mutation Each group of three bases corresponds to one of 20 different amino acids used to build a protein. If a mutation disrupts this reading frame, then the entire DNA sequence following the mutation will be read incorrectly.

Where would a frameshift mutation cause the most damage?

The effects of frameshifts are more dramatic when they occur in earlier parts of the gene. For example, if you had a gene made of 23 codons and the frameshift happened at codon 21, then only a small part of the protein would be changed.

Which of the following mutations does not result in a frameshift?

Insertion or deletion of three (or multiples of 3) nucleotides does not result in a frameshift mutation. It only results in the presence (or absence) of some amino acids in the polypeptide.

Can a point mutation be a frameshift mutation?

Some scientists recognize another type of mutation, called a frameshift mutation, as a type of point mutation. Frameshift mutations can lead to drastic loss of function and occur through the addition or deletion of one or more DNA bases.

Why are frameshift mutations more detrimental?

Because an insertion or deletion results in a frame-shift that changes the reading of subsequent codons and, therefore, alters the entire amino acid sequence that follows the mutation, insertions and deletions are usually more harmful than a substitution in which only a single amino acid is altered.

Why is frameshift mutation more harmful than point mutation?

How does frameshift mutation affect phenotype?

Frameshift mutations can lead to a premature end to translation of the mRNA as well as the formation of an extended polypeptide. The amino acid sequences downstream of the frameshift mutation are also likely to be chemically distinct from the original sequence.

Do all insertions and deletions cause Frameshifts?

A frameshift variant occurs when there is an addition or loss of nucleotides that shifts the grouping and changes the code for all downstream amino acids. The resulting protein is usually nonfunctional. Insertions, deletions, and duplications can all be frameshift variants.

What is a frameshift mutation and what causes it?

A frameshift mutation occurs when nucleotides are inserted into or deleted from the DNA and cause a “shift” in the reading of mRNA codons. Frameshift mutations are insertions or deletions of nucleotides in DNA that change the reading frame (the grouping of codons) and create mistakes during DNA synthesis.

Do all point mutations result in a change to phenotype?

All point mutations result in a change to phenotype. What is the most probable outcome of a frameshift mutation? A point mutation that occurred within an intron would most likely be characterized as a __________.

What are the effects of early a mutations?

A mutation that occurs early in the sequence could have more adverse effects, since it affects more nucleotides down the line. It is also possible that the mutated code contains an early stop/ termination codon/ (UAA, UAG, or UGA) and stops translation early, resulting in an abnormally short polypeptide.

What are the dangers of genetic mutations?

The dangers of any mutation usually include: An abnormally transcribed DNA sequence (mRNA) Resulting abnormal translated protein. An abnormal or lethal phenotype due to the mutated RNA and protein.