What is upstream and downstream in Pharmaceutical?

The production of active pharmaceutical ingredients (API) of biopharmaceuticals typically starts with generation of the API via living cells known as the upstream process, followed by purification of the target API, or the downstream process.

What is downstream and upstream manufacturing?

The manufacturing production process can be pictured like a river. Upstream refers to the material inputs needed for production, while downstream is the opposite end, where products get produced and distributed.

What is upstream processing in pharmaceutical manufacturing?

Upstream Processing refers to the first step in which biomolecules are grown, usually by bacterial or mammalian cell lines, in bioreactors. When they reach the desired density (for batch and fed batch cultures) they are harvested and moved to the downstream section of the bioprocess.

What is downstream manufacturing process?

Downstream in manufacturing refers to processes that occur later on in a production sequence or production line. The products being manufactured are created in a sequence of processes. Any process occurring after another is considered to be downstream.

What does downstream mean in manufacturing?

What is downstream production?

Which is downstream process?

Downstream processing refers to the recovery and the purification of biosynthetic products, particularly pharmaceuticals, from natural sources such as animal or plant tissue or fermentation broth, including the recycling of salvageable components and the proper treatment and disposal of waste.

What does downstream mean in medicine?

In genetics, at a stage in the sequence of processes in the expression of a gene that is nearer the final protein product than any stage in the direction of the DNA. The term is also used to mean in the direction of the 3′-end of a chain of bases in DNA (see PHOSPHODIESTER BOND).

What is downstream company?

Companies in the downstream sector are those that provide the closest link to everyday users. After crude oil is discovered and extracted—the upstream process—it’s shipped and transported—the midstream process. Thereafter, the oil is refined, marketed, distributed, and sold, which is the downstream process.

What is upstream and downstream processing?

Upstream & Downstream Processing The production of active pharmaceutical ingredients (API) of biopharmaceuticals typically starts with generation of the API via living cells known as the upstream process, followed by purification of the target API, or the downstream process.

What is downstream production of a drug?

Everything after the production of the drug substance is referred to as downstream. This includes all of the purification and enhancement steps, the viral inactivation steps, and polishing steps.

What are the steps involved in the drug manufacturing process?

The whole process of drug manufacturing can be divided into 3 broad steps namely, upstream, reactor phase and downstream. All the processing that is done before the reactor phase comes under upstream processing. This can mainly include preparation of inoculum ( active recombinant microbe), concentrating feed and antibiotic addition.

What is downstream processing in microbiology?

Downstream Processing Following the generation of the protein or antibody molecule, isolation and purification from the complex mixture of host cell proteins, cells, cell debris, nutrients and waste materials must now take place. Purification begins with separating the cells from the media.