What is a protein-protein interaction network?
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What is a protein-protein interaction network?
Definition. Protein–protein interaction networks are the networks of protein complexes formed by biochemical events and/or electrostatic forces and that serve a distinct biological function as a complex. The protein interactome describes the full repertoire of a biological system’s protein–protein interactions (PPIs).
How does PPI network work?
Protein–protein interaction (PPI) networks describe physical interactions between proteins, taking place to mediate the assembly of proteins into protein complexes, or e.g., mediating signaling/regulation and transport events in the cell.
What is the importance of Protein-Protein Interaction?
Protein-protein interactions (PPIs) play a crucial role in cellular functions and biological processes in all organisms. The identification of protein interactions can lead to a better understanding of infection mechanisms and the development of several medication drugs and treatment optimization.
Is Protein-Protein Interaction Networks database?
Protein-protein interactions have been retrieved from six major databases, integrated and the results compared. With respect to human protein-protein interaction data, HPRD seems to be the most comprehensive. To obtain a complete dataset, however, interactions from all six databases have to be combined.
What factors can influence interactions between proteins?
Protein-protein interaction Important affinity factors are the electrical charge of the surface, the hydrophobicity of the protein surface, the chemical functional groups on the pro- teins, the conformational stabilities and the sizes of the proteins.
How are protein coding genes identified?
It is the focus of this article. Putative protein-coding genes are identified based on computational analysis of genomic data—typically, by the presence of an open-reading frame (ORF) exceeding ≈300 bp in a cDNA sequence. Simply by chance, noncoding transcripts may contain long ORFs.