What does a high ceruloplasmin mean?

If your ceruloplasmin levels were higher than normal, it may be a sign of: A serious infection. Heart disease. Rheumatoid arthritis. Leukemia.

What causes elevated ceruloplasmin?

Your ceruloplasmin level can be higher than normal because of pregnancy, estrogen therapy, and birth control pills. Diseases such as leukemia, Hodgkin lymphoma, primary biliary cirrhosis, and rheumatoid arthritis can also cause a higher ceruloplasmin level.

What is the action of ceruloplasmin?

Thus, ceruloplasmin appeared to be essential to the normal movement of iron from cells to plasma. Studies designed to define the mechanism of action of ceruloplasmin were based on the in vitro observation that ceruloplasmin behaves as an enzyme (ferroxidase) that catalyzes oxidation of ferrous iron.

What can cause low ceruloplasmin?

Low levels of ceruloplasmin can be caused by several different factors:

• Long-term liver disease.
• Improper nutrition (malnutrition)
• Inability to absorb nutrients from food (malabsorption)
• Disorders that cause kidney damage (nephrotic syndrome)
• Disorder that makes your body unable to distribute copper (Menkes syndrome)

What are normal levels of ceruloplasmin?

Normal Results The normal range for adults is 14 to 40 mg/dL (0.93 to 2.65 µmol/L). Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or may test different samples.

How do you know if your CBC is normal?

CBC Results When you get your report, you’ll see two columns: a “reference range” and your results. If your results are inside the reference range, they’re considered normal. If your results are higher or lower than the reference range, they’re abnormal.

What is the normal range for ceruloplasmin?

Normal Results The normal range for adults is 14 to 40 mg/dL (0.93 to 2.65 µmol/L). Normal value ranges may vary slightly among different laboratories.

Why is ceruloplasmin high in inflammation?

Ceruloplasmin is an acute phase reactant and due to result of elevated gene transcription in hepatocytes, the concentration in serum is increased during inflammation, infection and trauma which are mediated by cytokines.

Is ceruloplasmin an antioxidant?

The antioxidant ceruloplasmin (Cp) is a copper-containing ferroxidase that can oxidize ferrous iron (Fe2+) to its nontoxic ferric (Fe3+) form. Cp is a highly effective antioxidant that can prevent oxidative damage to lipids, DNA, and proteins (3).

Is ceruloplasmin a globulin?

Ceruloplasmin is an α-globulin. Ninety percent of copper is bound to ceruloplasmin; each molecule binds six copper atoms, and albumin carries the remaining 10\% with less avidity (i.e., albumin donates copper more readily).

How is low ceruloplasmin treated?

The first treatment is to remove excess copper from your body through chelating therapy. Chelating agents include drugs like d-penicillamine and trientine, or Syprine. These drugs will remove the extra copper from your organs and release it into the bloodstream. Your kidneys will then filter the copper into the urine.

Is ceruloplasmin high or low in Wilson’s disease?

Serum ceruloplasmin levels are low in newborns and gradually rise within the first 2 years of life. Approximately 90\% of all patients with Wilson disease have ceruloplasmin levels of less than 20 mg/dL (reference range, 20-40 mg/dL).

What is the half life of apoceruloplasmin?

Apoceruloplasmin is largely degraded intracellularly in the hepatocyte and the small amount that is released has a short circulation half life of 5 hours as compared to the 5.5 days for the holo-ceruloplasmin.

What is caeruloplasmin used for?

Ceruloplasmin (or caeruloplasmin) is a ferroxidase enzyme that in humans is encoded by the CP gene. Ceruloplasmin is the major copper-carrying protein in the blood, and in addition plays a role in iron metabolism. It was first described in 1948.

How does aceruloplasminemia affect the body?

Aceruloplasminemia is a disorder in which iron gradually accumulates in the brain and other organs. Iron accumulation in the brain results in neurological problems that generally appear in adulthood and worsen over time. People with aceruloplasminemia develop a variety of movement problems.

What does it mean if your Ceruloplasmin is low?

Lower-than-normal ceruloplasmin levels may indicate the following: Wilson disease (a rare [UK incidence 2/100,000] copper storage disease). Greater-than-normal ceruloplasmin levels may indicate or be noticed in: Normal blood concentration of ceruloplasmin in humans is 20–50 mg/dL.