What causes Cipn?

Chemotherapy-induced peripheral neuropathy (CIPN) is a common problem occurring in approximately 30\%–40\% of those treated with neurotoxic chemotherapy. Traditional chemotherapeutic agents causing CIPN are the platinum, taxanes, and vinca alkaloid medications. These drug classes cause CIPN by direct neuronal toxicity.

What causes neuropathy during chemo?

Neuropathy is a common side effect of chemotherapy. Doctors believe it happens because chemotherapy damages healthy cells, including nerves. Chemotherapy can damage nerves that affect feeling and movement in the hands and feet.

Does vincristine cause neuropathy?

Vincristine is a core chemotherapeutic drug administered to pediatric acute lymphoblastic leukemia patients. Despite its efficacy in treating leukemia, it can lead to severe peripheral neuropathy in a subgroup of the patients.

Why do taxanes cause neuropathy?

The mechanisms of CIPN induced by taxanes: Taxanes cause microtubule disruption, which impairs axonal transport and leads to Wallerian degeneration, altered activity of ion channels and hyperexcitability of peripheral neurons.

What drugs cause Cipn?

What drugs are most likely to cause CIPN?

• Platinum drugs like cisplatin, carboplatin, and oxaliplatin.
• Taxanes, including paclitaxel (Taxol®), docetaxel (Taxotere®), and cabazitaxel (Jevtana®)
• Plant alkaloids, such as vinblastine, vincristine, vinorelbine, and etoposide (VP-16)

What is a taxane drug?

A type of drug that blocks cell growth by stopping mitosis (cell division). Taxanes interfere with microtubules (cellular structures that help move chromosomes during mitosis). They are used to treat cancer. A taxane is a type of mitotic inhibitor and a type of antimicrotubule agent.

What helps neuropathy in feet from chemo?

In the meantime, symptoms can be treated with:

1. steroids to reduce inflammation.
2. topical numbing medicines.
3. antiseizure medications, which can help relieve nerve pain.
4. prescription-strength pain relievers such as narcotics (opioids)
5. antidepressants.
6. electrical nerve stimulation.
7. occupational and physical therapy.

What are the three types of neuropathy?

Peripheral Neuropathy Types

• Motor neuropathy. This is damage to the nerves that control muscles and movement in the body, such as moving your hands and arms or talking.
• Sensory neuropathy.
• Autonomic nerve neuropathy.
• Combination neuropathies.

Why is vincristine neurotoxic?

It is thought that vincristine may cause axonal damage (and peripheral neuropathy) by the disruption of neurotubules and conse- quent impairment of axoplasmic transport mechanisms (21,22).

What does vincristine do to cells?

Vincristine is a chemotherapy drug that belongs to a group of drugs called vinca alkaloids. Vincristine works by stopping the cancer cells from separating into 2 new cells. So, it stops the growth of the cancer.

Why does Taxol cause peripheral neuropathy?

Paclitaxel induced neuropathy is probably due to dysfunctional microtubules in dorsal root ganglia, axons and Schwann cells [10, 11].

What is the mechanism of action of vincristine?

The mechanism of action of vincristine sulfate has been related to the inhibition of microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. Central nervous system leukemia has been reported in patients undergoing otherwise successful therapy with vincristine sulfate.